Involvement of the Wnt/β-catenin pathway in the ovulation process

BAS D; TESONE M; IRUSTA G; ABRAMOVICH D; ACCIALINI P; PARBORELL F

Mar del Plata

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2016

Sociedad Argentina de Investigación Clínica (SAIC), Sociedad Argentina de Fiosología (SAFIS) y Sociedad Argentina de Farmacología Experimental (SAFE).

Involvement of the Wnt/β-catenin pathway in the ovulation processAccialini Paula, Irusta Griselda, Bas Diana, Parborell Fernanda, Abramovich Dalhia, Tesone MartaThe evolutionarily conserved Wnt/β-catenin signal transduction pathway controls many biological processes. Previous results from our lab showed that the canonical Wnt pathway is involved in ovulation and luteinization. The objective of this study was to deepen in the role of the Wnt/β-catenin pathway in the ovulation process. To this purpose prepubertal eCG-treated rats were injected with a Wnt inhibitor (XAV939) or vehicle (DMSO, Control group) into the bursa of both ovaries the day of hCG administration. Two days after hCG and Wnt inhibitor or vehicle injection, ovaries were collected and fixed in Bouin solution for histological analysis. We found a significant decrease in the percentage of Corpora Lutea (p