Rol of neurosteroids, steroid receptors and the GABAergic pathway on the exacerbated neurogenesis of the GABA B receptor KO mouse

GARAY LAURA; LIMA ANALIA; ALEJANDRO DE NICOLA; DI GIORGIO N; BETTLER B.; GONZALEZ DENISELLE, MARIA CLAUDIA; LUX-LANTOS V

Mar del Plata

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2016

SAIC

Adult hippocampal neurogenesis is regulated through the interaction of neural progenitor cells with diverse signals in the dentate gyrus. These signals include, among others, neurotrophins, neurotransmitters, and steroids. γ-Aminobutyric acid (GABA) signaling through GABAA receptors positively regulates the entire process of neurogenesis while GABAB receptor exerts an inhibitory role. Here, we analyzed the influence of GABA and the steroidogenic pathway on the exacerbated neurogenesis observed in the GABAB1 receptor knockout mice (GABAB KO). GABAB KO showed a 2.2 fold increase in the number of doublecortin (DCX)+ cells vs. WT (p