IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Overconsumption of sucrose during the juvenile stage imprints long-­term changes in the Nucleus Accumbens.
Autor/es:
KRUSE M.S.; COIRINI, H.; COTARELO M.
Lugar:
CABA
Reunión:
Congreso; XVIII Jornadas Anuales Multidisciplinarias Sociedad Argentina de Biología; 2016
Institución organizadora:
Sociedad Argentina de Biología
Resumen:
Sucrose consumption has increased dramatically in our society. This phenomenon is mainly associated with increased obesity and diabetes, among other metabolic disorders. Of particular interest are the youngest populations since they have the highest sugar consumption and, during this period of life, profound changes occur as part of the maturation of the CNS. However, little is known about the impact of overconsumption of sucrose on the developing CNS. Here we studied the effect of unlimited access of sugary water during the juvenile stage (childhood-adolescence) on the expression of neuronal proteins involved in the structure, function and inflammatory responses in areas belonging to the limbic system, system related to motivation and reward. In parallel, the effects of excessive sucrose consumption were tested in adulthood. The long-term expression of cFos, p-AKT, AKT-T, GFAP, NeuN and PCNA were analyzed by Western blot in the nucleus accumbens (nAcc), the medial prefrontal cortex (mPFC) and the ventral hippocampus (HIPv). We found that the nAcc is particularly sensitive to the overconsumption of sucrose at early stages of development, but not in adulthood. cFOS was increased (p