Pharmacological effects of testosterone in a mouse model of motoneuron disease.

LARA AGUSTINA; GARAY L; SCHUMACHER M; GONZALEZ DENISELLE MC; GARGIULO MONACHELLI GISELLA; MEYER M; LUX-LANTOS V; DI GIORGIO N; GUENNOUN R; DE NICOLA A. F.

Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC).; 2016

Wobbler (WR) mouse, a useful model for human amyotrophic lateral sclerosis (ALS), shows motoneuron degeneration with increased levels of intramitochondrial nitric oxide synthase (NOS) and astrogliosis in the spinal cord. Some steroids such as progesterone favor mitochondrial function and neuroprotection, while others are deleterious. Here, we determined endogenous testosterone (T) levels in male WRs and controls by radioimmunoassay and gas chromatography/mass spectrometry (GC/MS) at symptomatic stage. We demonstrated a strong decrease of T levels in serum, spinal cord and brain (p