EFFECTS OF NATIVE PLANTS DECOCTION FROM CUYO ON SERUM PARAMETERS OF RATS WITH EXPERIMENTAL DIABETES

DELGADO, J.F.; COIRINI, H.; REY, M.; MAGRINI-HUAMAN, R.N; TAPIA, A.; FERESIN, G. E,

Ciudad Autonoma de Buenos Aires

Congreso; XVIII Jornadas Anuales Multidisciplinarias de la Sociedad Argentina de Biología; 2016

Sociedad Argentina de Biologia

Diabetes mellitus is a chronic disease with great global distribution, thus the search of new therapeutic alternatives is constant. Several studies indicate that 85% of world population still uses ?medicinal plants? to be healthy. In particular, in the region of Cuyo (Argentine), Oxalis erythrorhiza (Oe) and Tessaria absinthiodes (Ta) species are consumed to regulate the glycaemia (Glu) and the cholesterol level (Chol), although those effects lack of scientific support. Male rats (SD) of 42 days, controls (C, i.p. vehicle) or with experimental diabetes (D, i.p. streptozotocin 30mg/Kg) received 10% decoctions of Oe (DOe and COe), Ta (DTa and CTa), or water (DW and CW) like only drink for 4 weeks. Glu, Chol and triglycerides (TG) were determined on samples obtained weekly with colorimetric kits. At the end of the treatment, Glu and TG were higher in the D than the C (200% and 170% respectively; p<0.05), while Chol was lower (30%; p<0.05). Glu values on DOe and DTa were lower than DW (34% and 30% respectively; p<0.05), and in these groups a increasing TG and a decreasing Chol trend was observed. The decoctions intake did not alter plasmatic parameters on C groups. These preliminary results show that Oe and Ta could have regulatory effects on Glu. To asses some other properties in these native plants decoctions, a longer treatment and two other dilutions are being performed with the same experimental model. (CAM-2 SECITI-UCCUYO 2015; PIP 0243; PIO-SECITI150 2015-0100022).