IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
( 8 1 1 ) ROLE OF THE IMMUNE SYSTEM IN ANTIPROGESTIN- INDUCED MAMMARY TUMOR REGRESSION
Autor/es:
SEQUEIRA GR; VANZULLI S; DALOTTO-MORENO T; LAMB C; NOVARO V; SAHORES A; LANARI C ; POLO L; SALATINO M
Reunión:
Congreso; Reunion ANual de la SAI-SAIC-SAFE; 2016
Resumen:
The role of the immune system in the regression of mammarycarcinomas C using endocrine therapies has been poorly investigated.e have shon that mifepristone F, antiprogestininduces the regression of murine C that express progesteronereceptors regardless of the immune system. Characterization ofthe immune cells in regressing tumors may provide clues relatedto their role in the prevention of tumor regroth. ur aim as tocharacterize the infiltrating cells in Ftreated C and to evaluatehether F as able to protect against tumor groth in atumor rechallenge assay after complete tumor resection. onemarro cells from AL/cF mice ere iv inoculatedinto immunodeficient S mice to establish the S/Fmouse model. H tumors, originated in AL/c mice, ereinoculated into S or S/F female mice. F pellets. mg ere implanted sc hen the tumors reached mm2.Tumors ere excised after or days and isolated cells analyzedby flo cytometry. An increase in T lymphocytes Cand in macrophages Cb F p., and a decreasein the Treg subpopulation C C Foxp p., as observedin Ftreated tumors. n the rechallenge assay, tumorsere excised and pellets removed days after F treatment.Animals ere orthotopically reinoculated ith H tumors inthe opposite flan days after surgery. Sham operated animalsere used as controls. All secondary transplants groing inuntreated mice reached 200 mm2 before day hile only of those mice previously treated ith F reached thissize, p.. The reduced intratumor Treg/C ratio observedin regressing tumors might be used as a predictive marer oftreatment response. In sum, the data presented herein agreeith the hypothesis that regressing tumors expose intracellularantigens that generate a protective immune memory response,hich could be associated ith the long free relapse survivalinduced by endocrine therapy.