IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
M2 macrophages inhibit IFN-g production of NK cells through TGF-b and NK cell-mediated cytotoxicity through cell-to-cell contact
Autor/es:
SECCHIARI FLORENCIA; ARAYA ROMINA ELIZABETH; NUÑEZ SOL YANEL; TORRES NICOLÁS IGNACIO; FUERTES MERCEDES BEATRIZ; RAFFO IRAOLAGOITIA XIMENA LUCÍA; ZWIRNER NORBERTO WALTER; ZIBLAT ANDREA; SIERRA JESSICA MARIEL; DOMAICA CAROLINA INÉS
Lugar:
Mar del Plata
Reunión:
Congreso; LXIV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2016
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
Macrophages are highly plastic cells that can modify their functional response according to the surrounding microenvironment, becoming pro-inflammatory (M1) or anti-inflammatory (M2) macrophages. The outcome of the crosstalk between M1 and NK cells is well established playing a critical role in the protection against infections and tumor growth. However, the effect of M2 on NK cells is less clear. We previously demonstrated that M2 macrophages inhibit NK cell degranulation (n=8, p