alpha-(2,6) Sialylation Shapes the Function of Mucosal B Cells in Experimental Models of Inflammatory Bowel Diseases (IBD)

MOROSI, LUCIANO; MORALES, ROSA; MARIÑO, KARINA VALERIA; MAY, MARÍA; RABINOVICH, GABRIEL A.; CUTINE, ANABELA; MARTINEZ ALLO, VERONICA; TOSCANO, MARTA A

Toronto

Conferencia; Mucosal Immunology Course and Symposium (MICS 2016); 2016

Society of Mucosal Immunology

The glycome of immune cells has the potential to regulate cellular processes relevant to immune tolerance and disease. Sialic acids are common monosaccharides found in cell surface glycans, and play fundamental roles in B-cell physiology. Here, we aim to examine the impact of α(2,6) sialylation (α2,6sia) in B-cell functionality during the development of intestinal inflammation. Working with α(2,6) sialyltransferase deficient mice (ST6gal1-/-), we found that lack of α(2,6)sia decreased the number of IgA plasma cells (PCs) in the colonic lamina propria (LP) (p