IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The Histamine H4 Receptor Is Detected in Neonatal Human Leydig Cells, and in Prepubertal Leydig Cells Tumors. Possible Involvement in Neonatal Leydig Cells Pool Preservation
Autor/es:
ALIBERTI P; MONDILLO C; ABIUSO MB; PIGNATARO OP; RIVAROLA M; BELGOROSKY A; BERENSZTEIN E
Lugar:
San Diego
Reunión:
Congreso; 97th Annual Meeting. The Endocrine Society.; 2015
Institución organizadora:
The Endocrine Society
Resumen:
Histamine (HA) is an endogenous biogenic amine synthesized from L-histidine exclusively through the catalytic activity of histidine decarboxylase (HDC). HDC is expressed by testicular mast cells and germ cells (1). HA is now known to elicit a vast spectrum of physiological and pathological actions, including the pathogenesis of several tumors, through binding to four G protein-coupled receptors, designated as HRH1-4 (2). Accordingly, numerous studies have documented the ability of HA to modulate steroidogenesis through H1R and H2R in rodents Leydig cells, and their proliferation under pathological conditions [3]. In human testes of fertile and infertile patients, the expression of H1R, and H2R by germinal, interstitial, and peritubular cells was reported (4). The H4 receptor (H4R), the newest member of the family, is considered a promising drug target for allergy, inflammation, autoimmune disorders, and cancer [5]. Very recently, we reported for the first time that H4R is functionally expressed in murine Leydig cells, and that its selective activation can significantly inhibit gonadotropin-stimulated stereoidogenesis via a reduction in cAMP levels [6). However, there is no information available on HR4 expression in immature human testes.