HYPOTHALAMIC LIVER X RECEPTORS (LXR). THEIR RELATIONSHIP WITH THE INTERMEDIATE METABOLISM

COIRINI, H.

Mendoza

Workshop; International Workshop in Neuroendocrinology 2015; 2015

International Neuroendocrinology Organization

The prevalence of chronic diseases like type 2 diabetes and Alzheimer´s disease (AD) is increasing as a result of nutritional factors, obesity, sedentary lifestyle and longevity of individuals. Insulin levels play an important role in the link between the two diseases. LXR are nuclear receptors important in the regulation of lipid metabolism and carbohydrate. The activation of LXR facilitates cellular cholesterol excretion therefore they has been considered promising candidates for treating diseases such as atherosclerosis and AD. On the other hand the LXR activation by synthetic analogs improves glucose tolerance. Studies from our laboratory have shown that LXR are expressed in different brain areas but the expression in the hypothalamus is particularly sensitive to sustained hyperglycemia, indicating a possible regulatory function on the metabolism of glucose. Using different glucose intolerant models we have described changes in the expression of hypothalamic LXR that could be associated with the central control of blood glucose. Moreover, these receptors are also sensible to different fat rich diets. These data suggest that hypothalamic LXR would play a central role on the regulation of the intermediate metabolism. However, it is still unknown whether the altered expression in the hypothalamus is associated with a change in the receptor functionality and which ones are the responses associated (CONICET- PIP860 and PIP243).