Food intake, body weight and leptin sensitivity in hyperprolactinemic lactotrope Drd2KO female mice

LUQUE GM; LÓPEZ-VICCHI F; DE-WINNE C; ORNSTEIN AM; PEREZ-MILLAN MI; BECÚ-VILLALOBOS D

Mendoza

Workshop; International Workshop in Neuroendocrinology (IWNE); 2015

Prolactin, a pleiotropic hormone secreted by lactotropes, participates in metabolic processes by binding to its receptor (PrlR). In this context, to evaluate the effect of chronically elevated prolactin levels within a preserved GH axis, we used a conditional mutant mouse that selectively lacks Drd2 from pituitary lactotropes (lacDrd2KO). We studied the role of elevated prolactin levels on body weight and food intake during both ad-libitum and fast-refed conditions. Furthermore, we evaluated serum leptin levels and sensitivity in lacDrd2KO female mice in comparison with their controls (Drd2loxP/loxP). LacDrd2KO female mice showed a significant increase in body weight since 5 months of age. Furthermore, in the context of a fast-refed situation we found that lacDrd2KO female mice lost less weight (p*