Astroglial alterations from early to late stages in a model of Alzheimer?s disease: evidence of autophagy involvement in amyloid- beta internalization.

POMILIO C; GOROJOD RM; VINUESA A; ALAIMO A; APARICIO E; TODERO MF; KOTLER ML; BEAUQUIS J; SARAVIA F

Mar del Plata

Congreso; Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2015

Sociedad Argentina de Investigación en Neurociencias

Alzheimer?s disease (AD) is the principal cause of dementia in the elderly. One histopathological hallmark of AD is the presence of senile plaques, extracellular deposits principally composed of amyloid-β (Aβ) peptides, which are normally surrounded by reactive glia. We studied early alterations in hippocampal astrocytes and their progression during the degenerative process in PDAPP transgenic mice, a model of AD. At 3 months of age, before plaques formation, we found less number of GFAP+ astrocytes in the stratum radiatum under CA1 (p