Regulated glycosylation controls the fate and function of regulatory T cells

MENDEZ-HUERGO, SANTIAGO P.; DALOTTO MORENO, TOMAS; CROCI, DIEGO O.; CERLIANI, JUAN PABLO; MARIÑO, KARINA; TOSCANO, MARTA A; RABINOVICH, GABRIEL A.

Medellín

Congreso; 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología; 2015

Upon differentiation into a specific subset, CD4+ T cells undergo major changes in their glycosylation profile. We have previously demonstrated that Th1, Th17 and Th2 cells exhibit differential glycosylation patterns on their cell surface, leading to differential sensitivity to the endogenous lectin galectin-1 (Gal1). Here we investigated the impact of glycosylation in the function of T cells, focusing on regulatory T cells (Tregs). First we analyzed by mass spectometry the N-glycosylation patterns of in vitro induced Tregs (iTregs) versus in vitro non-polarized activated T cells (Teff). iTregs exhibited significantly lower levels of highly-branched complex N-glycans (p