IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Endocrine Disruption in the Hipothalamic-Pituitary Unit. Effects of Bisphenol A
Autor/es:
FERNANDEZ MARINA
Reunión:
Jornada; XVI JORNADAS ANUALES DE LA SOCIEDAD ARGENTINA DE BIOLOGÍA; 2014
Resumen:
Bisphenol A (BPA) is a monomer of polycarbonates and a constituent of epoxy and polyestirene resins. BPA can exert its actions through estrogen receptors, acting as an agonist or antagonist; it can also antagonize the effects of the thyroid hormone and of androgens; and it can modulate enzymatic activity, among other mechanisms. In vivo effects have also been described in several studies. We observed that the neonatal exposure to BPA affects the hypothalamic-pituitary-gonadal axis in female Sprague-Dawley rats. It induces precocious puberty, alters gonadotropin, prolactin and sex hormone levels, and it also induces ovarian alterations similar to the ones observed in Polycystic Ovarian Syndrome (PCOS). It alters the in vitro respose to gonadotropin releasing hormone (GnRH), modifying GnRH-induced signaling pathways in primary pituitary cultures from rats neonatally exposed to BPA. It also alters the hypothalamic-pituitary-thyroid axis. Furthermore, it has direct effects in primary pituitary cultures from thirteen day old female rats. The results described here provide interesting data about the neuroendocrine effects of a controversial endocrine disruptor: Bisphenol A.