RELEVANCE OF THE GALECTIN-1 (GAL1)-N-GLYCAN AXIS IN THE DEVELOPMENT OF SPONTANEOUS SIALADENITIS

VERONICA MARTINES ALLO; VANESA HAUK; ROSA MORALES; JUAN STUPIRSKI; ESTEBAN MARONNA; NICOLAS PINTO; CLAUDIA PEREZ LEIROS; GABRIEL RABINOVICH; MARTA TOSCANO

Mar del Plata

Congreso; LXii Reunion Científica Anual de la Sociedad Argentina de Inmunología; 2014

Gal1, an endogenous β-galactoside-binding protein, plays a critical role in immune cell homeostasis. Administration of recombinant Gal1 suppresses clinical signs of autoimmunity and chronic inflammation. However, the relevance of endogenous Gal1 in the development of spontaneous autoimmunity has not yet been reported. We have previously demonstrated that aged Gal1 deficient mice (Lgals1-/-) (~20 month) have increased eight and show augmented signs of inflammation in salivary glands compared to WT mice (P