IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CRITICAL ROLE OF GALECTIN-1 IN FETOMATERNAL TOLERANCE
Autor/es:
S. BLOIS; J. ILARREGUI; M. GARCIA; M. TOSCANO; G. BIANCO; G. RABINOVICH; P. ARCK
Lugar:
RIO DE JANEIRO
Reunión:
Congreso; 13TH INTERNATIONAL CONGRESS OF IMMUNOLOGY; 2007
Institución organizadora:
ICI 2007
Resumen:
Critical role of galectin-1 in fetomaternal tolerance
Author Block: S. M. Blois1, J. M. Ilarregui2, M. Garcia1, M. A. Toscano2, G. A. Bianco2, G. A.
Rabinovich2, P. C. Arck1;S. M. Blois1, J. M. Ilarregui2, M. Garcia1, M. A. Toscano2, G. A. Bianco2, G. A.
Rabinovich2, P. C. Arck1;2, P. C. Arck1;
1Charit¨¦, University Medicine Berlin, Berlin, Germany, 2Lab Immunogenetics, Hospital de Cl¨ªnicas,
UBA, Buenos Aires, Argentina.Charit¨¦, University Medicine Berlin, Berlin, Germany, 2Lab Immunogenetics, Hospital de Cl¨ªnicas,
UBA, Buenos Aires, Argentina.
Abstract:
Blastocyst implantation and perpetuation of pregnancy requires a coordinated adaptation of the
immune and endocrine system. Galectins can modulate the immune responses and a member of this
protein family, galectin-1 (gal-1) is abundant in the female reproductive tract and placental tissue.
We hypothesized that this immunoregulatory protein might play a pivotal role in regulating
fetomaternal tolerance. In the present study we found that uterine Gal-1 expression is downregulated
in challenged murine pregnancies. Consistently, gal-1-/- mice exhibited increased rejection
rates compared to wild-type mice even in undisturbed pregnancies (p<0.01). Treatment with
recombinant Gal-1 prevented fetal rejections and restored multiple tolerance mechanisms including
expansion of CD4+CD25+IL-10+ regulatory T cells in vivo, up-regulation of Th2 cytokines,
increased IDO expression and activation of negative inflammatory pathways; i.e TGF-¦Â1 and Stat-3.
In addition, galectin-1 promotes the generation of CD11c+ uterine DC with CD80/86lo and IL-10hi-/- mice exhibited increased rejection
rates compared to wild-type mice even in undisturbed pregnancies (p<0.01). Treatment with
recombinant Gal-1 prevented fetal rejections and restored multiple tolerance mechanisms including
expansion of CD4+CD25+IL-10+ regulatory T cells in vivo, up-regulation of Th2 cytokines,
increased IDO expression and activation of negative inflammatory pathways; i.e TGF-¦Â1 and Stat-3.
In addition, galectin-1 promotes the generation of CD11c+ uterine DC with CD80/86lo and IL-10hi¦Â1 and Stat-3.
In addition, galectin-1 promotes the generation of CD11c+ uterine DC with CD80/86lo and IL-10hilo and IL-10hi
phenotype with a regulatory function in the development of successful pregnancies. Finally, we
provide evidence for a functional cross-talk between Gal-1 and the LH/progesterone axis in the
maintenance of pregnancy. The present study demonstrates a novel role for Gal-1 as a pivotal and
upstream messenger in the maintenance of fetomaternal tolerance and identifies a novel therapeutic
target aiming at restoring immune tolerance in threatened pregnancies
:
Author Disclosure Block: S.M. Blois, None; J.M. Ilarregui, None; M. Garcia, None; M.A.
Toscano, None; G.A. Bianco, None; G.A. Rabinovich, None; P.C. Arck, None., None; J.M. Ilarregui, None; M. Garcia, None; M.A.
Toscano, None; G.A. Bianco, None; G.A. Rabinovich, None; P.C. Arck, None., None; G.A. Bianco, None; G.A. Rabinovich, None; P.C. Arck, None.
Keyword (Complete): reproductive immunology ; regulatory T cells ; dendritic cells ; Galectin-1: reproductive immunology ; regulatory T cells ; dendritic cells ; Galectin-1
Topic (Complete): AIA-09 Reproductive and newborn immunology ; ADR-11 Regulatory T cells: AIA-09 Reproductive and newborn immunology ; ADR-11 Regulatory T cells
Submission Fee (Complete)::
Credit Card : True: True
Status: CompleteComplete
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