METABOLIC EFFECTS OF DIETARY OLIVE AND PISTACHIO OILS SUPPLEMENTATION IN THE OFFSPRING OF DIABETIC RATS

MAGRINI-HUAMA;N, R.N; COIRINI, E.; VEGA, M.C.; REY, M.; IGHANI, M.; FERESIN, G. E,; TAPIA, A.; COIRINI, H.

Estancia Grande

Congreso; XXXII Reunion Anual de la Sociedad de Biologia de Cuyo; 2014

Sociedad de Biologia de Cuyo

Changes in the intrauterine environment during pregnancy affect fetal development. Uncontrolled diabetes during the pregnancy is highly correlated with metabolic abnormalities in the adult offspring. Inclusion of monounsaturated fatty acids in the diet, have shown beneficial effects on certain metabolic parameters. The offspring of an experimental model of streptozotocin-induced gestational diabetics  (30 mg/Kg iv) (DO) and controls mothers (CO) were used to assess the effect of the intake of corn oil (MZ), extra virgin olive oil (OL) and pistachio oil (PS). Cholesterol levels (Chol), triglyceride (TG), fasting plasma glucose (Glu), and fructosamine (Fru) were evaluated. Supplementation was performed during 2-62 days of age (dose: 8μl/15g weight). The samples were collected from 10 month old fasted animals. Results: Significant increase on Chol levels were observed in DO vs CO (1.24 times; p <0.01) as well as 1.4 times increase in females vs males (p <0.01). PS supplement produced a 61% reduction in females (p <0.01). TG levels did not show significant changes due the condition CO-DO, but they were affected by OL or PS supplement in both sexes (p <0.01). Glu levels were partially affected by oils supplementation (p <0.01). Fru levels increased in DO and up regulated by OL en males (p <0.01). The prenatal diabetes causes changes that are partly reversed by the inclusion of OL or PZ in the diet (CONICET, PICTO/UCCuyo 2009-0158- CICITCA UNSJ).