146. Evolution of Prediabetic Condition in Aged Mice Lacking Functional Gabab Receptors

CRIVELLO, M; BONAVENTURA MM; LIBERTUN C; LUX LANTOS V

Congreso; ICE/ENDO 2014; 2014

EVOLUTION OF PREDIABETIC CONDITION IN AGED MICE LACKING FUNCTIONAL GABAB RECEPTORS Martín Crivello(1), María Marta Bonaventura(1), Bernhard Bettler (2), Carlos Libertun(1,3) and Victoria Lux-Lantos(1). (1) Neuroendocrinology Laboratory, IBYME-CONICET. (2) University of Basel, Basel, Switzerland. (3) School of Medicine, University of Buenos Aires, Argentina. During the past years the role of GABA in endocrine pancreas function has emerged as an increasingly active area of study. Previously, we demonstrated adult GABAB-receptor knock-out mice (GABABKO) to suffer disruptions in glucose homeostasis (1-3). As insulin resistance increases with age, here we followed survival and glucose homeostasis parameters in 7-11 month old male and female GABABKO and WT mice. We found no differences in body weight, fasting serum insulin or the HOMA insulin-resistance index (HOMA-IR) among groups at 200, 250 or 300 days, while we had detected an increase in the later two parameters in young adult GABABKO males. No differences were found in fasting glucose in male mice; females had higher blood glucose at 250 and 300 days vs. 200 days (p