IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Exposure to arsenite alters metabolism and sexual hormones inpregnant rats
Autor/es:
M.M. BONAVENTURA; N.S. BOURGUIGNON; D. RODRÍGUEZ; C. LIBERTUN; V. LUX LANTOS
Lugar:
Buenos Aires
Reunión:
Congreso; 5º Congreso Internacional sobre el Arsénico en el Medio Ambiente; 2014
Institución organizadora:
International Society of groundwater for sustainable development
Resumen:
Arsenic is a naturally occurring metalloid; the most common source of contamination is from ground water. In Argentina population exposure is close to 10%, being pregnant women and children among the most vulnerable. Arsenic impact on the metabolic and reproductive axes is being widely studied; nowadays it is also considered an endocrine disruptor. The aim of the present study was to elucidate the effect of arsenic exposure on the metabolic and reproductive axes of pregnant rats. Rats exposed to 5 (A5) or 50 (A50) ppm of As (III) in drinking water starting day 1 of pregnancy presented glucose intolerance on gestational day 16 (GD16). A50 also presented augmented serum estradiol and testosterone at GD18, and diminished body weight at GD21. These observations are of vital importance since changes during pregnancy in both metabolism and sexual hormones have been widely related to alterations in offspring as well as in dams themselves.