IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Insulin and glucose differ between normal weight dogs, healthy obese dogs and dogs with hyperadrenocorticism
Autor/es:
MICELI DD; RICART MC; CASTILLO VA; GÓMEZ NV; CABRERA BLATTER MF
Lugar:
Praga
Reunión:
Congreso; 31st World Veterinary Congress; 2013
Resumen:
Introduction: Glucose intolerance, insulin resistance and
hyperinsulinemia are associated to obesity and Cushing's syndrome (CS).
The aim of the study was to analyze whether the response to oral
tolerance test of glucose shows differences among dogs with CS, obese
and with normal weight.
Materials and methods: 6 healthy
normoweight dogs (controls), 6 obese without concurrent endocrine
disease or any other disease and 6 dogs with CS were studied. All dogs
were subjected to test of oral glucose tolerance (4g/kg) measuring blood
glucose and insulin in the basal (0), 15, 30, 60 and 120 minutes. Also
the HOMA-a (insulin resistance) and HOMA-b (β-cell function) index were
calculated taking for this parameters the baseline glucose and insulin
values. The results were analyzed using the nonparametric ANOVA test
followed Dunn?s test of multiplecomparision of medians.
Results:
blood glucose and insulin concentrations were significantly higher in
dogs with CS at times 0 (p <0.05), 15, 30 (p <0.001) and 60 (p
<0.05) vs. obese and controls. HOMA-a and HOMA-b were significantly
higher (p <0.01) in dogs with CS than obese and controls. Among the
obese and controls these values did not show significant differences.
Conclusion:
The hypercortisolism is a key factor to determine insulin resistance
and glucose intolerance. Dogs with CS have greater possibility of
rapidly deplete the pancreatic β-cell and develop Diabetes Mellitus.