Role of central hepatic X receptors on the glycemic control

KRUSE, M.S.; MAGRINI-HUAMAN, R.N.; DI PILLA, M. R.; BRUNO, M.; REY, M.; VEGA, M.C.; COIRINI, H.

BS AS

Simposio; Frontiers in Biosciences; 2012

Sociedad Max Planck y el Ministerio de Ciencia, Tecnología e Innovación Productiva

Certain metabolic consequences from one disease can be considered as risk factors for the expression of others, this is the case between diabetes or obesity and cardiovascular risks or Alzheimer´s disease. Alterations in lipid and carbohydrate metabolism are common in all these pathologies so as it is the action of oxisteroids. These steroids play an important regulatory effect on both lipid and carbohydrate metabolisms through its receptors. The present study was aimed to evaluate the presence of specific receptors for oxisteroids (LXRá and LXRâ) in the hypothalamus (HT) of 9 months old animals of both sexes, born from diabetic (OD) and controls (OC) mothers. An experimental model of gestational diabetes was generated and the response to a glucose load (CTG) was studied in all animals, prior to sacrifice. The expression of LXRs was evaluated by western blot. The OD animals showed glucose intolerance. LXRá expression in HT showed an increase in diabetic offspring that was significant in the males. Regarding the LXRâ a decrease was observed OD respect to OC in males while an increase was found in OD vs OC in females (p <0.05). Significant correlations were observed between the levels of hypothalamic LXRâ and area under the CTG. The results indicate that gestational diabetes affects neuronal circuits of the offspring differently in males than in females. In 9 month old animals there is an altered expression of LXRs in the HT, which could be related to the ability to properly regulate a glucose load.