Todo sobre mi madre: Nuevas relaciones para diferenciación decidual

MESTRE-CITRINOVITZ, ANA; SARAGÜETA, PATRICIA

Buenos Aires

Seminario; Seminarios IBYME 2012; 2012

IBYME

Although decidua is critical in implantation, the hormonal regulated pathway of decidualization is still elusive. Here we describe progesterone (PR) and estrogen receptors (ER) functions in in-vivo endometrial differentiation and propose a new role for ERK activation. We injected pregnant rats with oil, PR (ONA) and ER (ICI) antagonists, and their combination at 5 and 6dpc, and analyzed morphology, phERK, desmin, cyclin D3 and PCNA expression on 7dpc implantation sites. The early ONA treatment completely avoided decidua development. While the combination with ICI rescued reabsorption, increased phERK level and decreased differentiation markers, desmin and cyclinD3, as compared with oil injected uteri, the treatment with ICI alone did no change morphology neither these protein expression. These results suggest that balance of PR and ER is crucial for decidualization and Erk activation could compensate PR and ER loss of function.