Emerging roles of ATF2 and the dynamic AP1 network in cancer.

PABLO LOPEZ BERGAMI; ERIC LAU; ZEEV RONAI

NATURE REVIEWS CANCER

NATURE PUBLISHING GROUP

Año: 2010 vol. 10 p. 65 - 76

1474-175X

Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.