IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
Autor/es:
SUSPERREGUY S, MUÑOZ L, TKALENKO NY, MASCANFRONI ID, ALAMINO VA, MONTESINOS MM, MASINI-REPISO AM, MIRAS MB, PELLIZAS CG
Revista:
CLINICAL ENDOCRINOLOGY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2010
ISSN:
0300-0664
Resumen:
Objective: Idiopathic short stature (ISS) describes short children with
normal GH secretion. Although GH treatment increases their heights,
growth response to the therapy differs among patients. Thyroid hormones
(TH) are essential for longitudinal growth acting mainly through TH
receptors (TR) α and β. We have previously reported that GH treatment
reduced peripheral TH action in Turner Syndrome by TR down-regulation.
The aims of the study were to assess the effect of GH treatment to ISS
on peripheral TH action and the correlation between thyroid status and
growth response to the therapy. Subjects, design and measurements:
Eighteen normal (control) and twenty five ISS children were enrolled and
evaluated before and after 12 months of life time (control) or 12
months of GH therapy (ISS). Fasting blood was used for serum biochemical
evaluations, peripheral blood mononuclear cells for TR mRNA
determination by QRT-PCR and growth parameters by standard methods.
Results: GH treatment modified neither TR mRNA levels nor serum markers
of TH action in ISS evaluated as a whole group. However, the individual
change in TRβ mRNA levels correlated to the change in SHBG levels after
GH therapy. The growth response to GH correlated positively with the
change in TRα mRNA level and negatively with that in TRβ mRNA, TSH and
SHBG levels. The change in each TR mRNA isoform after GH treatment
correlated negatively with its own basal level. Conclusions: GH therapy
induced individual changes in TR expression in ISS that correlated with
their growth response. The basal TR mRNA level could predetermine the
change in TR expression and therefore the sensitivity to GH treatment.