IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer
Autor/es:
LANARI C; LAMB CA; HELGUERO LA; SOLDATI R; BOTTINO MC; GIULIANELLI S; CERLIANI JP; WARGON V; MOLINOLO AA
Revista:
ENDOCRINE - RELATED CANCER
Editorial:
BIOSCIENTIFICA LTD
Referencias:
Año: 2009 vol. 16 p. 330 - 350
ISSN:
1351-0088
Resumen:
More than 60% of all breast neoplasias are ductal carcinomas expressing estrogen (ER) and progesterone receptors (PR). By contrast, most of the spontaneous, chemically or mouse mammary tumor virus induced tumors, as well as tumors arising in genetically modified mice do not express hormone receptors. We developed a model of breast cancer in which the administration of medroxyprogesterone acetate to BALB/c female mice induces mammary ductal carcinomas with a mean latency of 52 weeks and an incidence of about 80%. These tumors are hormone-dependent (HD), metastatic, express both ER and PR, and are maintained by syngeneic transplants. The model has been further refined to include mammary carcinomas that evolve through different stages of hormone dependence, as well as several hormone-responsive cell lines. In this review, we describe the main features of this tumor model, highlighting the role of PR as a trigger of key signaling pathways mediating tumor growth. In addition, we discuss the relevance of this model in comparison with other presently used breast cancer models pointing out its advantages and limitations and how, this model may be suitable to unravel key questions in breast cancer.