IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Invasive Giant Prolactinoma with Loss of Therapeutic Response to Cabergoline: Expression of Angiogenic Markers
Autor/es:
MARÍA SUSANA MALLEA-GIL; CAROLINA CRISTINA; MARÍA INÉS PÉREZ MILLÁN; ANA M. RODRIGUEZ VILLAFAÑE; CAROLINA BALLARINO; GRACIELA STALLDECKER; DAMASIA BECÚ-VILLALOBOS
Revista:
ENDOCRINE PATHOLOGY
Referencias:
Año: 2009 vol. 20 p. 35 - 40
ISSN:
1046-3976
Resumen:
The present study reports the case of a 70-yearold Caucasian man who was referred to the Military Hospital of Buenos Aires for evaluation of a giant sellarextrasellar mass with extension in the right temporal lobe and compression of the third ventricle. Patient was initially responsive to cabergoline with reduction of prolactin levels and shrinkage of tumor burden for at least 36 months. Thereafter, prolactin levels and tumor size increased even though cabergoline dosage was increased. Transcraneal surgery was performed at 56 months of treatment. Prolactin levels and tumor proliferation did not subside and the patient died 14 months later. High GH and IGF-I levels were observed in the late stages of tumor development, with no evidence of acromegalic features. Immunohistochemistry of the excised tumor revealed strong immunoreactivity for VEGF and FGF-2, two potent angiogenic factors, and CD31 (an endothelial marker) indicating high vascularization of the adenoma.