IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
MULTIPLE FUNCTIONAL TARGETS OF THE IMMUNOREGULATORY ACTIVITY OF GALECTIN-1: CONTROL OF IMMUNE CELL TRAFFICKING, DENDRITIC CELL PHYSIOLOGY AND T CELL FATE
Autor/es:
DIANNE COOPER; JUAN M. ILARREGUI; SUSANA A. PESOA; DIEGO CROCI; MAURO PERRETTI; GABRIEL A. RABINOVICH
Revista:
METHODS IN ENZYMOLOGY.
Editorial:
ELSEVIER ACADEMIC PRESS INC
Referencias:
Año: 2010
ISSN:
0076-6879
Resumen:
Abstract
In the postgenomic era, the study of the glycomethe whole repertoire of
saccharides in cells and tissueshas enabled the association of unique glycan
structures with specific physiological and pathological processes. The responsibility
for deciphering this biological information belongs to endogenous glycan-
binding proteins or lectins. Galectin-1, a prototypic member of a family of
structurally related proteins, has demonstrated selective antiinflammatory and
immunoregulatory effects either by controlling immune cell trafficking, finetuning
dendritic cell physiology and regulating T-cell fate. These regulatory
functions mediated by an endogenous glycan-binding protein may contribute to
fulfill the needs for immune cell homeostasis, including preservation of fetomaternal
tolerance and prevention of collateral damage as a result of microbial
invasion or autoimmune pathology. We will discuss here the conceptual framework
which led to the study of galectinglycan lattices as a novel paradigm of
immune cell communication in physiological and pathological processes and
will highlight selected methods and experimental strategies which have contributed
to the study of the immunoregulatory activities of this multifaceted
glycan-binding protein both in in vitro and in vivo biological settings.
structurally related proteins, has demonstrated selective antiinflammatory and
immunoregulatory effects either by controlling immune cell trafficking, finetuning
dendritic cell physiology and regulating T-cell fate. These regulatory
functions mediated by an endogenous glycan-binding protein may contribute to
fulfill the needs for immune cell homeostasis, including preservation of fetomaternal
tolerance and prevention of collateral damage as a result of microbial
invasion or autoimmune pathology. We will discuss here the conceptual framework
which led to the study of galectinglycan lattices as a novel paradigm of
immune cell communication in physiological and pathological processes and
will highlight selected methods and experimental strategies which have contributed
to the study of the immunoregulatory activities of this multifaceted
glycan-binding protein both in in vitro and in vivo biological settings.
1, a prototypic member of a family of
structurally related proteins, has demonstrated selective antiinflammatory and
immunoregulatory effects either by controlling immune cell trafficking, finetuning
dendritic cell physiology and regulating T-cell fate. These regulatory
functions mediated by an endogenous glycan-binding protein may contribute to
fulfill the needs for immune cell homeostasis, including preservation of fetomaternal
tolerance and prevention of collateral damage as a result of microbial
invasion or autoimmune pathology. We will discuss here the conceptual framework
which led to the study of galectinglycan lattices as a novel paradigm of
immune cell communication in physiological and pathological processes and
will highlight selected methods and experimental strategies which have contributed
to the study of the immunoregulatory activities of this multifaceted
glycan-binding protein both in in vitro and in vivo biological settings.in vitro and in vivo biological settings.