Active compounds present in Rosmarinus officinalis leaves and Scutellaria baicalensis root evaluated as new therapeutic agents for endometriosis

BASTON JI; GONZALEZ A; FERELLA L; FERELLA L; SINGLA JJ; SINGLA JJ; MERESMAN G; BILOTAS M; MERESMAN G; OLIVARES C; BILOTAS M; OLIVARES C; BASTON JI; GONZALEZ A

REPRODUCTIVE BIOMEDICINE ONLINE

REPRODUCTIVE HEALTHCARE LTD

Lugar: Amsterdam; Año: 2018 vol. 27 p. 769 - 782

1472-6483

Research question: Can carnosic acid (CA), rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis?Design: Primary stromal cell cultures were established from endometrial biopsies from endometriosis patients and controls. The human endometrial stromal cell line T-HESC was also used for in-vitro experiments. Endometriosis was surgically induced in BALB/c mice which were then randomly assigned to different treatment groups: CA 2mg/kg/day (n=11); CA 20mg/kg/day (n=10); RA 1mg/kg/day (n=11); RA 3mg/kg/day (n=10); WG 20mg/kg/day (n=12); intraperitoneal (i.p.) vehicle control (n=8) and oral (p.o.) vehicle control (n=11). CA and RA were administered i.p. through post-surgical days 14 to 28. WG was administered p.o. by intragastric gavage through post-surgical days 14 to 26.Results: CA, RA and WG significantly inhibited in-vitro cell proliferation in primary and T-HESC cell cultures (p