Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa

VEAUTE, C.; LIU, D.Y.; FURLONG, L.I.; BIANCOTTI, J.C.; BAKER, H.W.G.; VAZQUEZ-LEVIN, M.H.

FERTILITY AND STERILITY

Elsevier

Lugar: Nueva York; Año: 2009

0015-0282

The anti-acrosin monoclonal antibody AcrC5F10 inhibited proacrosin activation, proacrosin-human zona pellucida glycoprotein A (ZPA) binding, and the zona pellucida (ZP)–induced acrosome reaction of the ZP-bound spermatozoa but had no significant effect on sperm-ZP binding. These results suggest that proacrosin- acrosin may play an important role in the ZP-induced acrosome reaction of spermatozoa after primary binding to the ZP. (Fertil Steril 2009;-:-–-. 2009 by American Society for Reproductive Medicine.)2009;-:-–-. 2009 by American Society for Reproductive Medicine.)