IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Progesterone modulates pro-inflammatory cytokine expression profile after spinal cord injury: implications for neuropathic pain
Autor/es:
N.S. ADLER; S.L. GONZALEZ; M.C. RAGGIO; F. LABOMBARDA; M.F. CORONEL; A.F. DE NICOLA
Revista:
JOURNAL OF NEUROIMMUNOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 292 p. 85 - 92
ISSN:
0165-5728
Resumen:
Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. Glial cell activation and cytokine production contribute to the pathology of central neuropathic syndromes. In this study we evaluated the effects of progesterone, a neuroactive steroid, on pain development and the spinal expression of IL-1, its receptors (IL-1RI and IL-1RII) and antagonist (IL-1ra), IL-6 and TNF, and NR1 subunit of NMDAR. Our results show that progesterone, by modulating the expression of pro-inflammatory cytokines and neuronal IL-1RI/NR1 colocalization, emerges as a promising agent to prevent chronic pain after SCI.