Immune mediators associated to male infertility in a mouse model of DNA immunization with the sperm protease proacrosin

VIGNATTI P; VEAUTE, C*; GARCIA MI; VAZQUEZ LEVIN MH*,; RUSSI, R; VEIGA, MF

JOURNAL OF REPRODUCTIVE IMMUNOLOGY.

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2016 vol. 118 p. 28 - 35

0165-0378

The immune response has relevant physiological functions both in the male and female reproductive system, and must be tightly controlled to achieve a successful pregnancy. Several immune factors have been related to infertility, among them humoral and cellular immune responses triggered by sperm antigens. The present study was aimed at evaluating the immune profile induced by DNA immunization against the sperm protease proacrosin in CF1 male mice and its effect upon fertility. Immunized animals exhibited higher anti-proacrosin antibodies levels than controls (indirect ELISA), both in serum (p