Hormonal regulation of metabolism

CORNEJO, M.P.; HENTGES, S.T.; COIRINI, H.; MALIQUEO, M.; ELIAS, C.F.; BECU-VILLALOBOS, D.

JOURNAL OF NEUROENDOCRINOLOGY.

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2016

0953-8194

Given thecurrent environment in most developed countries, it is a challenge to maintaina good balance between calories consumed and calories burned, althoughmaintenance of metabolic balance is key to good health. Therefore,understanding how metabolic regulation is achieved and how the dysregulation ofmetabolism affects health is an area of intense research. Most studies arefocused on the hypothalamus, which is a brain area that acts as a key regulatorof metabolism. Among the nuclei that integrate the hypothalamus, the arcuatenucleus is one of the major mediators in the regulation of food intake. Theregulation of energy balance is also a key factor to ensure the maintenance ofany species because of the dependence of reproduction on energy stores.Adequate levels of energy reserves are necessary for proper functioning of thehypothalamus-pituitary-gonadal axis. This review discusses valuable datapresented in the 2015 edition of the International Workshop ofNeuroendocrinology concerning the fundamental nature of the hormonal regulationof the hypothalamus and the impact on energy balance and reproduction.