IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Immunophilins, Protein Chemistry and Cell Biology of a Promising New Class of Drug Targets
Autor/es:
GALIGNIANA MD
Revista:
CURRENT MOLECULAR PHARMACOLOGY
Editorial:
Betham Science Pub
Referencias:
Lugar: Bassum; Año: 2015 vol. 9 p. 3 - 4
Resumen:
             Theorigin of the family of proteins known as Immunophilinscan be traced back to the year 1969, when the first specific ligand wasdiscovered. By that time, an employee of a pharmaceutical company took with himsoil samples from the Alps as part of a program of the company to analyze thepresence of microorganisms able to produce new compounds of pharmaceuticalinterest, in particular antibiotics. From those samples was isolated a fungus (Tolypocladium inflatum) that shows theability to prevent the growth of other fungi. The active principle wasidentified as a cyclic undecapeptide, cyclosporine A, and its chemical synthesis was then published. The studies showed that cyclosporine A hasimmunosuppressive effect in various experimental models, which provided an extraordinary advance on the tissueand organ transplantation field since it was born by the end of the XIXcentury. At the beginning of the 80´s, cyclosporin A became a sort of miracletreatment to avoid organ rejection.