IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
MELATONIN UNDERLIES SEASONALITY IN MULTIPLE SCLEROSIS RELAPSES
Autor/es:
FAREZ MF; MASCANFRONI ID; MÉNDEZ-HUERGO SP; YESTE A; MURUGAIYAN G; GARO LP; BALBUENA AGUIRRE ME; PATEL B; YSRRAELIT MC; ZHU C; KUCHROO VK; RABINOVICH GA; QUINTANA FJ; CORREALE JORGE
Revista:
CELL
Editorial:
CELL PRESS
Referencias:
Lugar: United States; Año: 2015 vol. 162 p. 1338 - 1352
ISSN:
0092-8674
Resumen:
Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the CNS. These epidemiological observations suggest that environmental factors influence the disease course. Here, we report that melatonin levels, whose production is modulated by seasonal variations in night length, negatively correlate with multiple sclerosis activity in humans. Treatment with melatonin ameliorates disease in an experimental model of multiple sclerosis and directly interferes with the differentiation of human and mouse T cells. Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-α. These results suggest that melatonin is another example of how environmental-driven cues can impact T cell differentiation and have implications for autoimmune disorders such as multiple sclerosis.