IBYME 02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity
Autor/es:
V.A. ALAMINO; M.M. MONTESINOS; G.A. RABINOVICH; C.G. PELLIZAS
Revista:
Oncoimmunology
Editorial:
Taylor & Francis
Referencias:
Lugar: Abingdon; Año: 2015 vol. 5 p. 1 - 7
Resumen:
Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy
