IBYME 02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer
Autor/es:
SEQUEIRA G; VANZULLI S. I; ROJAS P; LAMB CA; COLOMBO L; MAY, M; MOLINOLO AA; LANARI C
Revista:
Oncotarget
Editorial:
Impact Journals
Referencias:
Lugar: Depew; Año: 2014 vol. 5 p. 3246 - 3260
ISSN:
1949-2553
Resumen:
There is clinical and experimental evidence suggesting that antiprogestins might be used for the treatment of selected breast cancer patients. Our aim was to evaluate the effect of albumin-bound paclitaxel (Nab-paclitaxel) and pegylated doxorubicin liposomes (PEG-LD) in combination with mifepristone (MFP) in experimental breast cancer models expressing different ratios of progesterone receptor (PR) isoforms A and B. We used two antiprogestin-responsive (PRA>PRB) and two resistant (PRA
