Molecular determinants of invasion in endometrial cancer. Clinical and transitional oncology

ABAL M; LLAURADO M; DOLL A; MONGE M; COLAS E; GONZALEZ M; HALLAZZOUZI H; DEMAJO S; CASTELLVI J; GARCIA A; RAMON Y CAJAL S; XERCAVINS J; VAZQUEZ-LEVIN MH; ALAMEDA F; GIL-MORENO A; REVENTOS J

Clinical and Transitional Oncology

Rigau M

Lugar: Barcelona; Año: 2007 vol. 9 p. 272 - 277

Endometrial carcinoma is the most common gynecological malignancy in the western world and the most frequent among infiltrating tumours of the female genital tract. Despite the characterisation of molecular events associated with the development of endometrial carcinoma, those associated with the early steps of infiltration and invasion in endometrial cancer are less known. Deep myometrial invasion correlates with more undifferentiated tumors,lymph-vascular invasion, node affectation and decreased global survival. In this review we present an overview on the molecular pathology of myometrial infiltration that defines the initial steps of invasion in endometrial cancer. Downregulation of E-cadherin as a main player of epithelial to mesenchymal transition, as well as modifications on other molecules involved in cell-cell contacts, render cells with a migratory phenotype. In addition, altered signalling pathways and transcription factors associate with myometrial invasion, histologic grade and metastasis.