IBYME 02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Expression profile of shelterin components in plasma cell disorders. Clinical significance of POT1 overexpression
Autor/es:
JULIETA PANERO; JORGE ARBELBIDE; DOROTEA FANTI; DANA KOHAN; HERNAN RIVELLO; GABRIEL RABINOVICH; IRMA SLAVUTZKY
Revista:
BLOOD CELLS MOLECULES AND DISEASES
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 2014 vol. 52 p. 134 - 139
ISSN:
1079-9796
Resumen:
In this study we analyzed the expression profile and the interactions of all shelterin components in patients with MM and MGUS, and correlated the results with hTERT expression, telomere length (TL) and clinical characteristics of the diseases. Bone marrow samples of 154 patients: 70 with MGUS and 84 with MM were studied. Gene expression was determined by real-time quantitative RT-PCR and TL was evaluated by terminal restriction fragments. A significant overexpression of TRF2, POT1 and hTERT in MM compared to MGUS was observed (p
