INTRODUCTION TO SPECIAL ISSUE: GLYCANS IN VASCULAR BIOLOGY

THIJSSEN VICTOR; RABINOVICH GABRIEL ADRIÁN

GLYCOBIOLOGY

OXFORD UNIV PRESS INC

Lugar: Oxford; Año: 2014 vol. 24 p. 1235 - 1236

0959-6658

Introduction to special issue: Glycans in vascular biology Victor L Thijssen1 and Gabriel A Rabinovich2,3 + Author Affiliations 1Angiogenesis Laboratory Amsterdam, Cancer Center Amsterdam, Departments of Medical Oncology and Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands 2Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires 1428, Argentina 3Laboratorio de Glicómica, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, Argentina Emerging findings suggest that glycans play central roles in vascular processes, including those involving endothelial cell signaling, angiogenesis, lymphangiogenesis, hemostasis, leukocyte trafficking and inflammation. This collection of specialized reviews seeks to illustrate specific examples of how glycans and their binding partners are integral to vascular biology with the ultimate goal of identifying open questions in this interdisciplinary field and to capitalize on this information for the design of novel diagnostic and therapeutic approaches. In the past few years, it has become more and more evident that glycans and glycan-binding proteins are integral to many processes linked to vascular biology, including the formation of new blood or lymphatic vessels by sprouting (angiogenesis or lymphangiogenesis), leukocyte trafficking and hemostasis (Varki et al. 2008).