IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
A prostaglandin D2 system in the human testis.
Autor/es:
SCHELL C, FRUNGIERI MB, ALBRECHT M, GONZALEZ-CALVAR SI, KOHN FM, CALANDRA RS, MAYERHOFER A.
Revista:
FERTILITY AND STERILITY
Editorial:
Elsevier Science, Editor-in-chief: Alan H. DeCherney, MD
Referencias:
Lugar: New York, Estados Unidos de América; Año: 2007 vol. 88 p. 233 - 236
ISSN:
0015-0282
Resumen:
As shown recently, cyclooxygenase 2 (COX2), the inducible key enzyme for the prostaglandin (PG) biosynthetic pathway, is abundantly present in interstitial cells of testes of men suffering from different forms of impaired spermatogenesis and sub- or infertility, but it is absent in human testes with normal spermatogenesis. Although the spectrum of the downstream products of COX2 action in testis, namely PGs, and their effects are not known, our results show that Prostaglandin D2 (PGD2) likely plays a role. We describe (a) PGD2 synthetases, as well as receptors for PGD2 (DP) in testicular interstitial cells of men suffering from spermatogenic damage and infertility, and report that (b) PGD2 is produced by and can affect Leydig cells of an animal model, which expresses testicular COX2 and DP.