IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
TOLERANCE SIGNALING MOLECULES AND PREGNANCY: IDO, GALECTINS AND THE RENAISSANCE OF REGULATORY T CELLS
Autor/es:
P. TERNESS,; A. MELLOR,; G. CHAOUAT,; G. RABINOVICH,; A. BETZ,; S. SAITO,; D. CLARCK
Revista:
AM J REPRODUCT IMMUNOL
Editorial:
Blackwell Munksgaard
Referencias:
Lugar: Copenhagen ; Año: 2007 vol. 58 p. 238 - 254
ISSN:
1046-7408
Resumen:
PROBLEM: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic ´fetal allograft´ still valid? METHOD OF STUDY: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. RESULTS AND CONCLUSION: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.