IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference.
Autor/es:
CROCI DO; RABINOVICH GA
Revista:
Oncoimmnunology
Editorial:
Landes Bioscience
Referencias:
Lugar: Autin; Año: 2014
Resumen:
Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.