IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
Autor/es:
MICELI, DIEGO; GARCÍA, JORGE; PESSINA, PAULA; HALL, PABLO; CABRERA BLATTER, MARÍA F; GALLELLI, MARÍA F ; CASTILLO, VÍCTOR
Revista:
VETERINáRNí MEDICíNA
Editorial:
VETERINARY RESEARCH INST
Referencias:
Año: 2014
ISSN:
0375-8427
Resumen:
Ectopic ACTH secretion is provoked by extra-pituitary tumours that secrete ACTH, constituting an infrequent type of Cushing Syndrome in the dog. Neuroendocrine tumours (NET) are characterised by the synthesis of peptides with hormone activity. A dog with clinical diagnosis of Cushing?s syndrome and presenting an abdominal tumour located in the area of the left adrenal gland was sent to the hospital. Cortisol was not inhibited at four and eight hours after the application of low-dose dexamethasone and the cortisol/creatinine ratio was elevated (93 × 10-6, reference values < 10 × 10?6). Plasma ACTH measurements were high (28.6 pmol/l, reference values 5.5?14.3 pmol/l). On computed tomography, the tumour was found in the meso-epigastrium, with both adrenal glands hyperplasic and no alteration of the pituitary image. The tumour was located between the two layers of the meso-colon and was removed using laparoscopy. After surgery, ACTH concentrations became normal and clinical signs remitted. The histopathological diagnosis was NET, with positive ACTH immunostaining.