ENDOGENOUS GLUCOCORTICOIDS PARTICIPATE IN RETINAL DEGENERATION DURING CONTINUOUS ILLUMINATION.

LOPEZ , E.M; JULIÁN, L.K.; CAPANI, F.; CYMERING C.B.; COIRINI, H.; LOPEZ-COSTA, J.J.

THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.

Taylor & Francis Group

Lugar: Londres; Año: 2007

0020-7454

Continuous illumination (CI) induces an oxidative stress of the retina which is involved in light induced retinal degeneration (LIRD). As the increase of glucocorticoids could also collaborate in the damage, adrenalectomized (ADX) and sham operated rats (CTL) were submitted to CI, and their eyes were studied at light and electron microscopic levels. After CI, ADX retinas were significantly thicker than CTL retinas. Retinal alterations appeared earlier and were more severe in CTL than in ADX retinas. Corticosterone levels increased gradually in the sera of CTL rats along CI.These results suggest that adrenalectomy attenuates LIRD supporting the hypothesis.