IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis.
Autor/es:
PAGOTTO, ROMINA; PEREYRA, ELBA NORA; MONZÓN, CASANDRA; MONDILLO, CAROLINA; PIGNATARO, OMAR PEDRO
Revista:
JOURNAL OF ENDOCRINOLOGY
Editorial:
BIOSCIENTIFICA LTD
Referencias:
Lugar: Bristol; Año: 2014 p. 15 - 28
ISSN:
0022-0795
Resumen:
Histamine (HA)
is a neurotransmitter synthesized in most mammalian tissues exclusively by
histidine decarboxylase enzyme. Among the plethora of actions mediated by HA,
the modulatory effects on steroidogenesis and proliferation in Leydig cells
(LCs) have been described recently. To determine whether the effects on LCs
reported could be extrapolated to all steroidogenic systems, in this study, we
assessed the effect of this amine on adrenal proliferation and steroidogenesis,
using two adrenocortical cell lines as experimental models, the murine Y1 cells
and the human NCI-H295R cells. Even when steroidogenesis was not modified by HA
in adrenocortical cells, the biogenic amine inhibited the proliferation of
H295R cells. This action was mediated by the activation of HRH1 subtype and an
increase in the production of inositol phosphates as second messengers, causing
a cell-cycle arrest in the G2/M phase. These results indicate a new role for HA
in the proliferation of human adrenocortical cells that could contribute to a
better understanding of tumor pathology as well as to the development of new
therapeutic agents.