IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
Autor/es:
GONZALEZ C; CALANDRA R; GONZALEZ-CALVAR SI
Revista:
Advances in Bioscience and Biotechnology
Editorial:
Scientific Research
Referencias:
Año: 2013 vol. 4 p. 1 - 7
ISSN:
2156-8456
Resumen:
ABSTRACTTransforming growth factor beta 1 (TGF-β1) is a key regulator that modulates male reproductive function. Testicular TGF-β1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, testis development and spermatogenesis. Several studies have indicated that TGF-β1 is involved in the tight balance between proliferative and apoptotic re- sponses in the Leydig cells. In the present review, we summarize the direct effects of this cytokine in Ley- dig cells under normal and pathological conditions. We analyze the effect of TGF-β1 in Leydig cells de- pending on the type of receptors involved in the sig- naling pathway of TGF-β1. Our group has been ana- lyzing the canonical and non canonical intracellular signaling pathways of TGF-β1 that are involved in the expression of proliferative and apoptotic markers in Leydig cells. On the basis of our studies and from those of other authors we conclude that the balance between the expression of TGF-β1 receptors and co receptors is of relevance in Leydig cell physiology and pathophisiology.