Striatal gating through up states and oscillations in the basal ganglia: implications for Parkinson?s disease

ZOLD CAMILA L; KASANETZ FERNANDO; POMATA PABLO E; BELLUSCIO MARIANO A; ESCANDE MARIELA E; GALIÑANES GREGORIO G; RIQUELME LUIS A; MURER M GUSTAVO

JOURNAL OF PHYSIOLOGY (PARIS)

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2012 vol. 106 p. 40 - 46

0928-4257

Up states are a hallmark of striatal physiology. Spontaneous activity in the thalamo-cortical network drives robust plateau depolarizations in the medium spiny projection neurons of the striatum. Medium spiny neuron firing is only possible during up states and is very tightly regulated by dopamine and NMDA receptors. In a rat model of Parkinson´s disease the medium spiny neurons projecting to the globus pallidus (indirect pathway) show more depolarized up states and increased firing. This is translated into abnormal patterns of synchronization between the globus pallidus and frontal cortex, which are believed to underlie the symptoms of Parkinson´s disease. Here we review our work in the field and propose a mechanism through which the lack of D2 receptor stimulation in the striatum allows the establishment of fixed routes of information flow in the cortico-striato-pallidal network.