IBYME 02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
Autor/es:
CAREAGA, V.; BUENO, C.A.; MUNIAIN, C.; ALCHÉ, L.E.; MAIER, M.S.
Revista:
NATURAL PRODUCT RESEARCH
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2012 p. 1 - 8
ISSN:
1478-6419
Resumen:
A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY,HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa.
