IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
Autor/es:
CORDO RUSSO RI; PICCIONI F; BARRIENTOS G; MAZZOLINI G; KLAPP BF; ALANIZ LD; GARCIA MG; BLOIS SM
Revista:
Current Trends in Immunology
Editorial:
Research Trends (P) Ltd.
Referencias:
Lugar: Kerala; Año: 2012 vol. 12 p. 81 - 94
ISSN:
0972-4567
Resumen:
Hyaluronan (HA) is a glycosaminoglycan
component of the extracellular matrix, where it
possesses functions in morphogenesis, tissue
injury and repair, inflammation, and tumorigenesis.
HA is synthesized by HA synthases (HAS) and is
degraded by hyaluronidases (HYAL). Increased
levels of HA in tumors, due to differential
expression of HAS and HYAL, are related
to tumor progression and metastasis. During
pregnancy, changes in HA deposition and
distribution indicate that HA participates in
preparation of the endometrial stroma for
reception of the embryo. While pregnancy is a
physiological state and cancer a complex and
unpredictable pathology, both trophoblast and
tumor cells share some proliferative, invasive,
and immune tolerance mechanisms that allow
establishment of pregnancy and tumor progression.
This indicates that the study of a physiological
condition such as pregnancy could help to find
HA in pathological and physiological processes: An overview
of HA metabolism in cancer and pregnancy
novel cancer treatment strategies. Abnormal HA
metabolism has been observed in cancer and
pathologies of pregnancy, thus indicating that HA
could be considered a key molecule, able to
regulate these processes. This review discusses
the role of HA in cancer and pregnancy: the study
of similarities and differences between both
models could lead to identification of new targets
for treatment of tumors or pregnancy-associated
pathologies.