IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Clinical endometritis in an Argentinean herd of dairy cows: Risk factors and reproductive efficiency
Autor/es:
GIULIODORI MJ; MAGNASCO R.P. ; BECU-VILLALOBOS D; LACAU-MENGIDO IM; RISCO CA; DE LA SOTA RL
Revista:
JOURNAL OF DAIRY SCIENCE
Editorial:
AMER DAIRY SCIENCE ASSOC-ADSA
Referencias:
Lugar: Champaign, Illinois; Año: 2012
ISSN:
0022-0302
Resumen:
The objectives of this study were to assess the clinical and metabolic risk factors for clinical endometritis, the likelihood for having a normal vaginal discharge during postpartum, and the effects of endometritis on milk yield, reproductive efficiency, and metabolic status in Holstein cows. The study was conducted in a commercial dairy herd (Cordoba, Argentina) where 303 Holstein cows were enrolled. Cows were body condition scored (BCS, 1 to 5) and tail bled on -14, 7, 21, 31, 41 and 50 d relative to parturition. Cows having a vaginal discharge with presence of pus between 21 and 41 dpp were diagnosed as having clinical endometritis. Plasma blood samples were analyzed for non-esterified fatty acids (NEFA), â-hydroxy butyric acid (BHBA) and blood urea nitrogen (BUN) using commercial kits and IGF-1, insulin, and leptin by RIA. Data were analyzed with PROC MIXED, PROC GENMOD and PROC PHREG from SAS. Abnormal calving and Puerperal metritis increased the risk for endometritis (AOR [adjusted odds ratio] = 2.21 for both). High prepartum NEFA and high postpartum BHBA increased the risk for endometritis (AOR = 1.003 and 1.001, respectively), whereas high prepartum BUN reduced it (AOR = 0.853). Cut-offs of 456.6 ìM NEFA and of 402.5 ìM BHBA had sensitivities of 0.69 and 0.58, and specificities of 0.88 and 0.86, respectively. The likelihood for having normal vaginal discharge increased with time (~1% x dpp) and with normal calving. Cows with endometritis 47 had higher milk yield than normal herdmates (27.8 ± 0.9 vs. 25.7 ± 0.4 kg/d), lower risk for pregnancy by 100 dpp (AOR = 0.10), higher non-pregnancy risk by 200 dpp (AOR = 2.87), and higher risk for culling than normal cows (AOR = 2.28). Cows with endometritis had lower hazard rate (HR = 0.44) for pregnancy and had ~70 d longer calving to conception intervals. Finally, endometritis had no effect on metabolic hormones. In conclusion, the risk for clinical endometritis increases with abnormal calving and puerperal metritis, as prepartum NEFA and postpartum BHBA concentrations increase. Prepartum NEFA and postpartum BHBA could be useful for the prediction of endometritis. Lastly, clinical endometritis has detrimental effects on reproductive efficiency since affected cows take longer to get pregnant and are at higher risk for culling.â-hydroxy butyric acid (BHBA) and blood urea nitrogen (BUN) using commercial kits and IGF-1, insulin, and leptin by RIA. Data were analyzed with PROC MIXED, PROC GENMOD and PROC PHREG from SAS. Abnormal calving and Puerperal metritis increased the risk for endometritis (AOR [adjusted odds ratio] = 2.21 for both). High prepartum NEFA and high postpartum BHBA increased the risk for endometritis (AOR = 1.003 and 1.001, respectively), whereas high prepartum BUN reduced it (AOR = 0.853). Cut-offs of 456.6 ìM NEFA and of 402.5 ìM BHBA had sensitivities of 0.69 and 0.58, and specificities of 0.88 and 0.86, respectively. The likelihood for having normal vaginal discharge increased with time (~1% x dpp) and with normal calving. Cows with endometritis 47 had higher milk yield than normal herdmates (27.8 ± 0.9 vs. 25.7 ± 0.4 kg/d), lower risk for pregnancy by 100 dpp (AOR = 0.10), higher non-pregnancy risk by 200 dpp (AOR = 2.87), and higher risk for culling than normal cows (AOR = 2.28). Cows with endometritis had lower hazard rate (HR = 0.44) for pregnancy and had ~70 d longer calving to conception intervals. Finally, endometritis had no effect on metabolic hormones. In conclusion, the risk for clinical endometritis increases with abnormal calving and puerperal metritis, as prepartum NEFA and postpartum BHBA concentrations increase. Prepartum NEFA and postpartum BHBA could be useful for the prediction of endometritis. Lastly, clinical endometritis has detrimental effects on reproductive efficiency since affected cows take longer to get pregnant and are at higher risk for culling.